Description

Egfr Inhibitor CAS NO 879127-07-8 is a potent and selective small molecule inhibitor of the Epidermal Growth Factor Receptor (EGFR), a key tyrosine kinase target in oncology research. This compound is crucial for advancing the development of targeted cancer therapies, particularly for non-small cell lung cancer (NSCLC) and other solid tumors. It serves as an essential research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on signal transduction pathways and drug discovery.

Application

• Oncology Research & Drug Discovery: Primary tool compound for studying EGFR signaling pathways, mechanism of action, and resistance mechanisms in cancer cell lines and animal models.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize novel EGFR inhibitors.
• Preclinical Studies: Critical for evaluating the efficacy, pharmacokinetics, and pharmacodynamics of EGFR-targeted therapeutic candidates.
• Academic Research: Enables fundamental biological research into cell proliferation, differentiation, and apoptosis regulated by the EGFR family.
• Pharmaceutical Intermediate: May serve as a key synthetic intermediate or precursor in the scalable production of advanced therapeutic candidates.

Basic Information

Product Name	Egfr Inhibitor
CAS No.	879127-07-8
Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.94 g/mol
Synonyms	Osimertinib; AZD9291; Mereletinib; N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)acrylamide; (2E)-N-{2-[(2-Dimethylaminoethyl)methylamino]-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl}but-2-enamide; EGFR Tyrosine Kinase Inhibitor AZD9291; Tagrisso (Brand Name)
EINECS	Contact for details

Quality Control

Our Egfr Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates and reference standards to support your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.