Description

Vismodegib CAS NO 879085-55-9 is a potent and selective small-molecule inhibitor of the Hedgehog signaling pathway. This compound is of critical importance in pharmaceutical research and development, specifically targeting the Smoothened (SMO) receptor. It is primarily required by pharmaceutical companies, biotechnology research institutions, and advanced academic laboratories engaged in oncology drug discovery and development.

Application

• Active Pharmaceutical Ingredient (API) for targeted cancer therapies.
• Reference Standard for analytical method development and quality control in pharmaceutical manufacturing.
• Biochemical Research tool for studying the Hedgehog signaling pathway in cellular and molecular biology.
• Preclinical Development for investigating efficacy and pharmacokinetics in animal models of basal cell carcinoma and other cancers.
• Process Chemistry and route scouting for synthetic optimization.
• Formulation Studies for developing stable and bioavailable drug products.

Basic Information

Product Name	Vismodegib
CAS No.	879085-55-9
Molecular Formula	C19H14Cl2N2O3
Molecular Weight	389.23 g/mol
Synonyms	GDC-0449; Erivedge (trade name); 2-Chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide; Hedgehog pathway inhibitor; SMO inhibitor; RG3616
EINECS	Contact for details

Quality Control

Our Vismodegib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet the stringent requirements for pharmaceutical intermediates and reference materials. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, residual solvents, and heavy metals are available upon request. We adhere to cGMP standards where applicable to support our global clientele in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 20 ppm
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.