Description

Crizotinib CAS NO 877399-52-5 is a potent and selective small-molecule inhibitor of anaplastic lymphoma kinase (ALK) and c-Met/HGFR receptor tyrosine kinases. This compound is of critical importance in pharmaceutical research and development as a targeted therapeutic agent. It is primarily required by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in oncology drug discovery, preclinical studies, and the development of novel cancer treatments.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of targeted cancer therapies.
• Reference Standard in analytical laboratories for quality control and method validation of pharmaceutical products.
• Biochemical Research tool for studying ALK and c-Met signaling pathways in cellular and molecular biology.
• Preclinical Development for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Process Chemistry and intermediate synthesis for the scale-up of pharmaceutical manufacturing.
• Oncology Drug Discovery as a lead compound for developing next-generation kinase inhibitors.

Basic Information

Product Name	Crizotinib
CAS No.	877399-52-5
Molecular Formula	C₂₁H₂₂Cl₂FN₅O
Molecular Weight	450.34 g/mol
Synonyms	PF-02341066; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine; Xalkori (trade name); PF02341066; Crizotinib free base; ALK inhibitor PF-02341066; 2-Pyridinamine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
EINECS	Contact for details

Quality Control

Our Crizotinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet the high standards required for pharmaceutical research and development. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, NMR, and MS. Our quality commitment aligns with cGMP principles where applicable for non-clinical grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.