Description

Trityl-Peg9-Azide CAS NO 877239-08-2 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a trityl (triphenylmethyl) protecting group and a terminal azide functionality. This compound is critical for the controlled, site-specific conjugation of biomolecules and payloads in advanced bioconjugation and drug delivery platform development. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and diagnostics industries who require high-purity, functional linkers for creating stable, well-defined conjugates.

Application

• Bioconjugation and ADC Development: As a key building block for constructing Antibody-Drug Conjugates (ADCs) and other protein-payload complexes via click chemistry (e.g., copper-catalyzed or strain-promoted azide-alkyne cycloaddition).
• PEGylation and Linker Chemistry: For introducing a hydrophilic PEG spacer with a protected hydroxyl group, enabling subsequent deprotection and functionalization to create complex molecular architectures.
• Proteomics and Biomaterial Functionalization: In the synthesis of probes, surfaces, and hydrogels for studying protein interactions, cellular targeting, and tissue engineering.
• Diagnostic Reagent Synthesis: Used in the development of labeled antibodies, peptides, and oligonucleotides for imaging and diagnostic assays.
• Polymer and Dendrimer Synthesis: Serves as a functional monomer or chain extender in the creation of smart polymers and dendritic structures with precise functionality.
• Solid-Phase Peptide Synthesis (SPPS): As a soluble, protected linker for the synthesis of complex peptides and peptide-PEG hybrids.

Basic Information

Product Name	Trityl-Peg9-Azide
CAS No.	877239-08-2
Molecular Formula	C58H81N3O19
Molecular Weight	1124.3 g/mol (approx.)
Synonyms	Trityl-PEG9-N3; Trt-PEG9-Azide; α-Trityl-ω-azido-nonaethylene glycol; Triphenylmethyl-PEG9-azide; Azido-PEG9-trityl alcohol; 2-[2-[2-[2-[2-[2-[2-[2-[2-(Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, 1-(triphenylmethyl) ether; N3-PEG9-O-Trityl; PEG9 spacer with trityl and azide.
EINECS	Contact for details

Quality Control

Every batch of Trityl-Peg9-Azide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and functional integrity. Our standard quality commitment includes HPLC purity ≥95% and full structural confirmation by NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Specifications can be tailored to meet the requirements of cGMP, ISO, or other relevant regulatory frameworks for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep containers sealed under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.