Description

1-Methyl-3-Thien-2-Yl-1H-Pyrazole-5-Carbonyl Chloride is a high-purity, reactive chemical intermediate featuring a pyrazole core functionalized with a thiophene ring and an acid chloride group. This compound matters for its critical role as a versatile building block in the synthesis of complex heterocyclic molecules, enabling the formation of amide bonds under mild conditions. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the pyrazole-thiophene scaffold contributes to biological activity.
• Material Science Research: Serves as a precursor for creating functional polymers, liquid crystals, and organic electronic materials due to its conjugated structure.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes (ABPs) and other molecular tools for studying enzyme function.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical companies offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	1-Methyl-3-Thien-2-Yl-1H-Pyrazole-5-Carbonyl Chloride
CAS No.	876316-45-9
Molecular Formula	C9H7ClN2OS
Molecular Weight	226.68 g/mol
Synonyms	1-Methyl-3-(thiophen-2-yl)-1H-pyrazole-5-carbonyl chloride; 3-(2-Thienyl)-1-methyl-1H-pyrazole-5-carbonyl chloride; 1-Methyl-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid chloride; 876316-45-9; 1-Methyl-3-thiophen-2-yl-1H-pyrazole-5-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-Thien-2-Yl-1H-Pyrazole-5-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high standards in pharmaceutical and advanced material research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.