Description

4-[[(tert-Butyldimethylsilyl)Oxy]Methyl]-2-Iodo-1,3-Thiazole is a high-value, organosilicon-protected heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it provides a versatile and reactive handle for constructing complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on nucleoside analogs, antiviral agents, and novel heterocyclic scaffolds where precise functionalization of the thiazole ring is critical.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Agrochemical Research: Used in the development of new fungicides and herbicides that leverage the bioactive thiazole core.
• Material Science: Serves as a precursor for functionalized ligands or monomers in specialty polymers and advanced materials.
• Cross-Coupling Reactions: The iodine atom at the 2-position makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to create diverse biaryl structures.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and the introduction of the protected hydroxymethyl group into lead compounds.
• Chemical Biology: Can be used to create probes or tagged molecules for studying biological processes.

Basic Information

Product Name	4-[[(tert-Butyldimethylsilyl)Oxy]Methyl]-2-Iodo-1,3-Thiazole
CAS No.	875548-60-0
Molecular Formula	C10H18INOSSi
Molecular Weight	355.30 g/mol
Synonyms	2-Iodo-4-(((tert-butyldimethylsilyl)oxy)methyl)thiazole; 4-(((tert-Butyldimethylsilyl)oxy)methyl)-2-iodothiazole; 2-Iodo-4-((tert-butyldimethylsilyloxy)methyl)thiazole; TBDMS-protected 2-iodo-4-hydroxymethylthiazole; 4-(Hydroxymethyl)-2-iodothiazole TBDMS ether; 875548-60-0; 4-[(tert-Butyldimethylsilyloxy)methyl]-2-iodo-1,3-thiazole
EINECS	Contact for details

Quality Control

Our 4-[[(tert-Butyldimethylsilyl)Oxy]Methyl]-2-Iodo-1,3-Thiazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.