Description

JNJ26854165 (Quisinostat) 2HCl is a potent and selective small-molecule inhibitor of histone deacetylase (HDAC) enzymes, supplied as a dihydrochloride salt. This compound is a critical research tool for investigating epigenetic regulation, cellular differentiation, and apoptosis in oncology and other therapeutic areas. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies for cancer and other diseases. The product is identified by CAS number 875320-31-3.

Application

• Biochemical Research: Used as a reference standard and active agent in enzymatic assays to study HDAC inhibition kinetics and mechanisms.
• Oncology Drug Discovery: Serves as a key pharmacophore and lead compound in the development of novel epigenetic therapies targeting various cancers.
• Cell Biology Studies: Applied in in vitro cell culture models to induce histone hyperacetylation, alter gene expression, and study effects on cell cycle arrest and apoptosis.
• Preclinical Development: Utilized in animal model studies to evaluate the pharmacokinetics, efficacy, and safety profiles of HDAC inhibitor candidates.
• Mechanism of Action (MoA) Studies: Essential for elucidating the role of specific HDAC isoforms in disease pathways and validating new therapeutic targets.

Basic Information

Product Name	JNJ26854165 (Quisinostat) 2HCl
CAS No.	875320-31-3
Molecular Formula	C21H23ClN4O3 • 2HCl
Molecular Weight	503.26 g/mol (free base: 414.88 g/mol)
Synonyms	Quisinostat dihydrochloride; JNJ-26854165; JNJ 26854165; N-Hydroxy-2-(4-((((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)carbamoyl)benzamide dihydrochloride; HDAC Inhibitor XI; UNII-9V8P23M8KJ
EINECS	Contact for details

Quality Control

Our JNJ26854165 (Quisinostat) 2HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring the material meets the stringent specifications required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.