Description

Jnj-26481585 is a potent and selective small molecule inhibitor targeting histone deacetylase (HDAC) enzymes, specifically identified by CAS NO 875320-29-9. This compound is a critical research tool for investigating epigenetic regulation, cellular differentiation, and apoptosis pathways in oncology and neurology research. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies engaged in the discovery and development of novel therapeutics for cancer and neurodegenerative diseases.

Application

• Biomedical Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies for cancer therapy development.
• Epigenetics Studies: A key reagent for modulating histone acetylation status to study gene expression and chromatin remodeling.
• Oncology Research: Investigated for its potential to induce cell cycle arrest and apoptosis in various cancer cell lines.
• Neurodegenerative Disease Models: Employed in research exploring HDAC inhibition as a therapeutic strategy for conditions like Alzheimer's and Huntington's disease.
• Biochemical Assay Development: Serves as a control compound in high-throughput screening (HTS) assays for HDAC inhibitor discovery.
• Chemical Biology: Utilized as a molecular probe to understand the specific roles of HDAC isoforms in cellular signaling pathways.

Basic Information

Product Name	Jnj-26481585
CAS No.	875320-29-9
Molecular Formula	C₂₁H₂₀N₄O₂
Molecular Weight	360.41 g/mol
Synonyms	Quisinostat; JNJ-26481585; 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-; HDAC Inhibitor IX; (2E)-N-Hydroxy-3-[4-({[2-(1H-indol-3-yl)ethyl](2-hydroxyethyl)amino}methyl)phenyl]prop-2-enamide
EINECS	Contact for details

Quality Control

Our Jnj-26481585 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.