Description

Cytidine, n-Benzoyl-2'-Deoxy-2'-Fluoro-2'-Methyl-, (2'R)- (9Ci) CAS NO 874638-98-9 is a high-purity, modified nucleoside derivative, specifically engineered for advanced pharmaceutical research and development. This compound is a critical building block in the synthesis of novel oligonucleotide therapeutics, including antisense drugs and siRNA, due to its ability to enhance stability and modulate biological activity. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in the development of next-generation genetic medicines and antiviral agents.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense Drug Development: Used to create oligonucleotides with improved nuclease resistance and binding affinity for target mRNA sequences.
• siRNA and miRNA Research: Incorporated into small interfering RNA (siRNA) or microRNA (miRNA) to enhance pharmacokinetic properties and therapeutic efficacy.
• Medicinal Chemistry: Serves as a sophisticated intermediate in the discovery and optimization of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and related pathways.
• Diagnostic Probe Development: Utilized in the design of labeled probes for genetic testing and molecular diagnostics requiring high specificity.

Basic Information

Product Name	Cytidine, n-Benzoyl-2'-Deoxy-2'-Fluoro-2'-Methyl-, (2'R)- (9Ci)
CAS No.	874638-98-9
Molecular Formula	C17H18FN3O5
Molecular Weight	363.34 g/mol
Synonyms	2'-Deoxy-2'-fluoro-2'-C-methylcytidine 5'-Benzoate; 1-(5-O-Benzoyl-2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl)cytosine; 2'-Fluoro-2'-C-methylcytidine 5'-benzoate; 5'-O-Benzoyl-2'-deoxy-2'-fluoro-2'-C-methylcytidine; (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-N-benzoylcytidine; 2'-F-2'-C-Me-Cytidine 5'-OBz; Bz-2'-F-2'-C-Me-Cytidine
EINECS	Contact for details

Quality Control

Our Cytidine, n-Benzoyl-2'-Deoxy-2'-Fluoro-2'-Methyl-, (2'R)- (9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines, and specifications can be developed to meet specific customer requirements for advanced therapeutic development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.