Description

Cyclopropanecarbonyl Chloride,1-Amino-,Hydrochloride (1:1) is a specialized chemical building block featuring both an amino group and an acid chloride functionality, protected as its hydrochloride salt. This unique bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those containing cyclopropane rings, which are prized for their conformational rigidity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclopropane moiety can enhance biological activity.
• Peptide Mimetics & Conjugation: The reactive acid chloride group enables coupling reactions to create peptide-like structures or for bioconjugation applications in medicinal chemistry.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized to create labeled compounds or affinity probes for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the pharmaceutical and biotechnology sectors.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride,1-Amino-,Hydrochloride (1:1)
CAS No.	874154-69-5
Molecular Formula	C4H7Cl2NO
Molecular Weight	156.01 g/mol
Synonyms	1-Aminocyclopropanecarbonyl chloride hydrochloride; 1-Amino-1-cyclopropanecarboxylic acid chloride hydrochloride; 1-AMCC hydrochloride; Cyclopropanecarboxylic acid, 1-amino-, chloride, hydrochloride (1:1); (1-Aminocyclopropyl)carbonyl chloride hydrochloride; 1-Aminocyclopropane-1-carbonyl chloride hydrochloride; 1-Carbamoylcyclopropyl chloride hydrochloride (deprecated); 1-Amino-cyclopropanecarboxylic acid chloride HCl salt
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride,1-Amino-,Hydrochloride (1:1) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for advanced intermediates, ensuring reliability for critical pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.