Description

4-Chloro-5-Iodo-7-Ss-D-Ribofuranosyl-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine is a sophisticated nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular kinases. Its unique halogenated pyrrolopyrimidine structure makes it indispensable for medicinal chemists and researchers in life sciences, biotechnology, and fine chemical synthesis who require high-purity, well-characterized intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside-based antiviral and anticancer prodrugs.
• Antiviral Drug Research: Precursor in the development of compounds targeting viral replication enzymes like polymerases and reverse transcriptases.
• Oncology Research: Used in the creation of kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Tool Compound: Utilized in enzymatic assays and as a probe to study nucleoside metabolism and transport.
• Fine Chemical Synthesis: Intermediate for the preparation of more complex, labeled, or conjugated nucleoside derivatives.

Basic Information

Product Name	4-Chloro-5-Iodo-7-Ss-D-Ribofuranosyl-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine
CAS No.	873792-94-0
Molecular Formula	C11H12ClIN4O4
Molecular Weight	426.59 g/mol
Synonyms	4-Chloro-5-iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-5-iodo-7-β-D-ribofuranosyl-; 4-Chloro-5-iodo-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 873792-94-0; Nucleoside analog intermediate; Halogenated pyrrolopyrimidine nucleoside
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-Iodo-7-Ss-D-Ribofuranosyl-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.