Description

5-Bromo-4-Chloro-7-Ss-D-Ribofuranosyl-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine is a high-purity nucleoside analog building block of significant importance in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of modified oligonucleotides, enabling the creation of novel therapeutic agents. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in developing antiviral drugs, antisense oligonucleotides, and other targeted molecular therapies.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite precursor for constructing oligonucleotides designed to modulate gene expression for therapeutic purposes.
• Antiviral Drug Development: Used in the research and production of nucleoside analog prodrugs targeting viral polymerases.
• siRNA and miRNA Research: Incorporated into small interfering RNA (siRNA) or microRNA (miRNA) strands to enhance stability and target specificity.
• Diagnostic Probe Manufacturing: Serves as a building block for labeled probes used in genetic testing and molecular diagnostics.
• Medicinal Chemistry & Lead Optimization: Employed in structure-activity relationship (SAR) studies to develop novel bioactive molecules.
• Bioconjugation and Labeling: The reactive halogen atoms provide sites for further functionalization with reporter groups or linkers.

Basic Information

Item	Detail
Product Name	5-Bromo-4-Chloro-7-Ss-D-Ribofuranosyl-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine
CAS No.	873792-93-9
Molecular Formula	C11H12BrClN4O4
Molecular Weight	379.60 g/mol
Synonyms	4-Amino-5-bromo-7-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 5-Bromo-2'-deoxy-4'-thiouridine; 5-Br-4-Cl-7-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4'-Thio-5-bromo-2'-deoxyuridine analog; BnCldU; Nucleoside Analog Intermediate; Pyrrolo[2,3-d]pyrimidine nucleoside
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-4-Chloro-7-Ss-D-Ribofuranosyl-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for pharmaceutical research. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.