Description

Gdc-0152 is a potent and selective small molecule inhibitor of the Inhibitor of Apoptosis Proteins (IAPs), specifically targeting cIAP1, cIAP2, and XIAP. This compound is a critical research tool for studying apoptosis regulation and has significant potential in the development of novel cancer therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, cell biology, and drug discovery programs.

Application

• Oncology Research: Used as a key pharmacological agent to study apoptosis pathways and evaluate the therapeutic potential of IAP inhibition in various cancer cell lines and animal models.
• Drug Discovery & Development: Serves as a reference compound and a lead structure for the design and synthesis of novel IAP antagonists and Smac mimetics.
• Biochemical Assays: Employed in in vitro assays to measure caspase activation, cell viability, and protein-protein interactions within apoptotic signaling complexes.
• Mechanistic Studies: Facilitates research into the role of IAPs in cell survival, proliferation, and resistance to chemotherapy and radiation.
• Preclinical Evaluation: Used in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies to support investigational new drug (IND) applications.

Basic Information

Product Name	Gdc-0152
CAS No.	873652-48-3
Molecular Formula	C₂₉H₄₀N₈O₄
Molecular Weight	564.68 g/mol
Synonyms	GDC-0152; GDC 0152; (S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-(4-(4-(((S)-2,3-dihydroxypropyl)amino)-3-nitrophenyl)thiazol-2-yl)piperazin-1-yl)-2-oxoethylamino)ethyl)-5-(isopropylamino)-4-methylpentanamide; IAP Inhibitor GDC-0152; SM-406; AT-406; Debio 1143; Xevinapant
EINECS	Contact for details

Quality Control

Our Gdc-0152 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure compliance with research-grade standards and support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.