Description

5'-Azido-5'-Deoxy-n-[(1,1-Dimethylethoxy)Carbonyl]-2',3'-o-(1-Methylethylidene)Adenosine is a sophisticated, protected nucleoside derivative designed for advanced synthetic chemistry. This compound is a critical building block in the synthesis of modified oligonucleotides and nucleotide analogs, where its azido and Boc-protected amine functionalities enable precise, site-specific modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and materials science applications.

Application

• Oligonucleotide Synthesis: A key intermediate for introducing azide groups into oligonucleotide backbones for "click chemistry" applications.
• Antiviral & Anticancer Prodrug Development: Serves as a precursor in the synthesis of nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: The azido moiety allows for efficient conjugation with alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach fluorescent dyes, affinity tags, or other functional groups.
• Chemical Biology Research: Used as a tool compound to study nucleic acid metabolism and to create probes for target identification and validation.
• Materials Science: Employed in the creation of functionalized surfaces and polymers for biosensing and nanotechnology.

Basic Information

Product Name	5'-Azido-5'-Deoxy-n-[(1,1-Dimethylethoxy)Carbonyl]-2',3'-o-(1-Methylethylidene)Adenosine
CAS No.	873556-44-6
Molecular Formula	C19H25N9O5
Molecular Weight	459.46 g/mol
Synonyms	5'-Azido-5'-deoxy-N-Boc-2',3'-O-isopropylideneadenosine; N-Boc-5'-azido-5'-deoxy-2',3'-O-isopropylideneadenosine; 5'-Azido-5'-deoxy-N-(tert-butoxycarbonyl)-2',3'-O-(1-methylethylidene)adenosine; 5'-N-Azido-N-Boc-2',3'-O-isopropylideneadenosine; Adenosine, 5'-azido-5'-deoxy-N-[(1,1-dimethylethoxy)carbonyl]-2',3'-O-(1-methylethylidene)-; Boc-5'-azido-5'-deoxy-2',3'-O-isopropylidene-Adenosine
EINECS	Contact for details

Quality Control

Our 5'-Azido-5'-Deoxy-n-[(1,1-Dimethylethoxy)Carbonyl]-2',3'-o-(1-Methylethylidene)Adenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is moisture-sensitive and should be handled in a dry environment. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.