Description

Infigratinib is a potent and selective small-molecule inhibitor of fibroblast growth factor receptors (FGFRs) 1-3. This targeted therapeutic agent is crucial for advancing oncology research and drug development, particularly in addressing cancers driven by FGFR pathway alterations. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on precision medicine for solid tumors.

Application

• Oncology Research & Drug Development: A key reference standard and active pharmaceutical ingredient (API) in the development of targeted cancer therapies.
• Biochemical Assays: Used as a selective inhibitor to study FGFR signaling pathways and their role in cell proliferation and survival.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy against FGFR-altered tumors, such as cholangiocarcinoma and urothelial carcinoma.
• Mechanism of Action (MoA) Studies: Essential for investigating the pharmacodynamics and resistance mechanisms of FGFR inhibition.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of novel therapeutic candidates within the same class.
• Quality Control & Analytical Testing: Used as a high-purity certified reference material (CRM) for HPLC, LC-MS, and NMR method development and validation.

Basic Information

Product Name	Infigratinib
CAS No.	872511-34-7
Molecular Formula	C31H34F3N5O3
Molecular Weight	581.63 g/mol
Synonyms	BGJ398; NVP-BGJ398; BGJ 398; (3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)imidazo[1,5-a]pyrazin-2(3H)-one); Fibroblast Growth Factor Receptor Inhibitor BGJ398; 1H-Imidazo[1,5-a]pyrazin-2(3H)-one, 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-8-[(4-morpholinyl)methyl]-
EINECS	Contact for details

Quality Control

Our Infigratinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and comprehensive residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.