Description

Propanoyl Chloride, 2-Hydroxy-2-Methyl- is a highly reactive acyl chloride derivative, primarily valued as a key building block for introducing the 2-hydroxy-2-methylpropanoyl moiety into target molecules. Its significance lies in enabling efficient synthesis of complex intermediates for pharmaceuticals, agrochemicals, and advanced materials. This compound is essential for R&D chemists and process development teams in the fine chemical, pharmaceutical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing molecules with tertiary alcohol and ester functionalities.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where the 2-hydroxy-2-methylpropanoic acid structure is required.
• Polymer Chemistry: Serves as a monomer or co-monomer in the production of specialty polyesters and polyacrylates with tailored properties.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organometallic catalysts for asymmetric synthesis.
• Surface Modification Agent: Used to functionalize surfaces of materials (e.g., silica, polymers) to alter wettability, adhesion, or biocompatibility.
• Cross-linking Agent: Acts as a reactive cross-linker in resin and coating formulations to enhance durability and chemical resistance.

Basic Information

Product Name	Propanoyl Chloride, 2-Hydroxy-2-Methyl-
CAS No.	871900-30-0
Molecular Formula	C4H7ClO2
Molecular Weight	122.55 g/mol
Synonyms	2-Hydroxy-2-methylpropanoyl chloride; 2-Methyl-2-hydroxypropionyl chloride; α-Hydroxyisobutyryl chloride; 2-Hydroxyisobutyryl chloride; Hydroxypivaloyl chloride; 2-Methyllactoyl chloride; Isobutyric acid, 2-hydroxy-, chloride
EINECS	Contact for details

Quality Control

Our Propanoyl Chloride, 2-Hydroxy-2-Methyl- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive analytical data, including HPLC/GC purity, identity confirmation (IR, NMR), and impurity profiling. Certificates of Analysis (COA) are available for every batch and supplied with each order to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.