Description

Trametinib is a highly potent and selective allosteric inhibitor of MEK1 and MEK2, key kinases in the RAS/RAF/MEK/ERK signaling pathway. This compound is a critical research tool and active pharmaceutical ingredient (API) for developing targeted cancer therapies. It is essential for pharmaceutical R&D, preclinical studies, and the manufacturing of oncology drugs targeting mutations in this pathway, such as those found in melanoma and non-small cell lung cancer.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of targeted cancer therapeutics.
• Biomedical Research: A vital tool for studying the MAPK/ERK pathway in cancer biology, signal transduction, and drug resistance mechanisms.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicology of MEK inhibition.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Combinatorial Therapy Studies: Investigated in combination with other targeted agents (e.g., BRAF inhibitors) for enhanced anti-tumor effects.

Basic Information

Product Name	Trametinib
CAS No.	871700-17-3
Molecular Formula	C26H23F4IN4O4
Molecular Weight	615.38 g/mol
Synonyms	GSK1120212; JTP-74057; MEKINIST (Trade Name); N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1(8H)-yl}phenyl)acetamide; 1H-Pyrido[4,3-d]pyrimidine-2,4,7(3H,6H,8H)-trione, 1-(3-acetamidophenyl)-3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-; Trametinib DMSO solvate
EINECS	Contact for details

Quality Control

Our Trametinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a dry environment and sealed tightly after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.