Description

Cal-101 is a potent and selective small molecule inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3Kδ). This compound is a critical research tool for investigating the role of PI3Kδ signaling in various biological processes, particularly in immune cell function and oncology. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on developing novel therapeutics for conditions like inflammatory diseases and hematological cancers.

Application

• Biochemical Research: A key reagent for studying PI3K signaling pathways, cellular proliferation, and apoptosis.
• Drug Discovery & Development: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies for oncology and immunology targets.
• Cell Biology Studies: Employed to modulate immune cell (e.g., B-cell, T-cell) activation and function in vitro.
• Pharmacology: Serves as a tool compound for validating PI3Kδ as a therapeutic target and for assessing efficacy in disease models.
• High-Throughput Screening (HTS): Used as a control in assay development and compound library screening campaigns.

Basic Information

Product Name	Cal-101
CAS No.	870281-82-6
Molecular Formula	C₂₂H₁₈FN₇O₃
Molecular Weight	447.42 g/mol
Synonyms	GS-1101; Idelalisib; 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone; CAL-101; PI3Kδ inhibitor; Phosphoinositide 3-kinase delta inhibitor; Zydelig (Pharmaceutical Brand Name)
EINECS	Contact for details

Quality Control

Our Cal-101 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.