Description

Talarozole CAS NO 870093-23-5 is a potent and selective retinoic acid metabolism-blocking agent (RAMBA) of the azole class. This compound is of significant interest in pharmaceutical research and development due to its mechanism of action, which modulates retinoic acid signaling pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for dermatological conditions and certain cancers.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) in the synthesis of investigational drugs.
• Dermatological Research: Used in preclinical and clinical studies targeting skin disorders such as psoriasis, acne, and ichthyosis by regulating keratinocyte differentiation.
• Oncology Research: Investigated for its potential role in cancer therapy, particularly for acute promyelocytic leukemia (APL) and other malignancies influenced by retinoic acid pathways.
• Biochemical Tool Compound: Employed in laboratory settings to study the effects of retinoic acid metabolism inhibition on cellular processes and gene expression.
• Metabolic Pathway Studies: Utilized to elucidate the role of cytochrome P450 enzymes, specifically CYP26, in retinoid homeostasis.

Basic Information

Product Name	Talarozole
CAS No.	870093-23-5
Molecular Formula	C21H21FN2O2
Molecular Weight	352.41 g/mol
Synonyms	R115866; Talarozole (R115866); 4-[1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-2-(4-fluoro-2-methylphenyl)-α,α-dimethyl-1H-imidazole-1-ethanol; 4-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluoro-2-methylphenyl)-α,α-dimethyl-1H-imidazole-1-ethanol; R-115866
EINECS	Contact for details

Quality Control

Our Talarozole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.