Description

2'-Amino-2'-Deoxy-5-Methyluridine is a modified nucleoside analog of significant interest in advanced pharmaceutical and biochemical research. This compound serves as a critical building block for the synthesis of oligonucleotides and other nucleotide-based therapeutics, enabling precise modifications to genetic material. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in the development of novel antiviral agents, anticancer drugs, and molecular probes. The compound, identified by CAS No. 869729-38-4, offers a pathway to engineer nucleic acids with enhanced stability and targeted biological activity.

Application

• Antiviral Drug Development: As a key intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Oncology Research: Used in the creation of modified nucleotides for anticancer prodrugs and targeted cancer therapies.
• Oligonucleotide Synthesis: A vital phosphoramidite precursor for solid-phase synthesis of antisense oligonucleotides, siRNA, and aptamers.
• Biochemical Probes: Incorporation into DNA/RNA strands to study enzyme mechanisms, polymerase activity, and nucleic acid interactions.
• Diagnostic Reagent Manufacturing: Serves as a component in the production of labeled nucleotides for diagnostic assays and sequencing.
• Academic & Pharmaceutical R&D: Fundamental research tool for exploring novel mechanisms of action and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	2'-Amino-2'-Deoxy-5-Methyluridine
CAS No.	869729-38-4
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	5-Methyl-2'-deoxy-2'-aminouridine; 2'-Amino-2'-deoxy-5-methyluridine; 2'-Amino-5-methyl-2'-deoxyuridine; 2'-Deoxy-2'-amino-5-methyluridine; 5-MethyldUrd(2'NH2); 2'-NH2-5-Me-dU; 2'-Amino-5-methyl-deoxyuridine; 2'-Amino-2'-deoxy-5-methyl-uridine
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxy-5-Methyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption, which can compromise product stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.