Description

n-[4-Amino-5-(2,3-Difluoro-6-Methoxybenzoyl)-2-Pyrimidinyl]-1-(Methylsulfonyl)-4-Piperidinamine Monomethanesulfonate is a high-purity, non-racemic pharmaceutical intermediate and research chemical of significant commercial interest. This compound is valued for its role as a key building block in the synthesis of advanced, targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in developing novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of investigational new drugs, particularly in oncology and other therapeutic areas.
• Biochemical Research: Used as a reference standard or active agent in pharmacological studies to investigate enzyme inhibition and cellular signaling pathways.
• Process Development & Scale-Up: Serves as a key material for optimizing synthetic routes and scaling production from laboratory to pilot and commercial scale.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the final stages or penultimate steps of API manufacturing for targeted therapies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and drug discovery projects.

Basic Information

Product Name	n-[4-Amino-5-(2,3-Difluoro-6-Methoxybenzoyl)-2-Pyrimidinyl]-1-(Methylsulfonyl)-4-Piperidinamine Monomethanesulfonate
CAS No.	869369-26-6
Molecular Formula	C19H22F2N6O5S2
Molecular Weight	516.54 g/mol
Synonyms	4-Piperidinamine, N-[4-amino-5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-pyrimidinyl]-1-(methylsulfonyl)-, methanesulfonate (1:1); UNII-9J97361D2I; 9J97361D2I; BMS-599626; BMS599626; BMS 599626; (R)-N-[4-Amino-5-(2,3-difluoro-6-methoxybenzoyl)pyrimidin-2-yl]-1-(methylsulfonyl)piperidin-4-amine methanesulfonate
EINECS	Contact for details

Quality Control

Every batch of n-[4-Amino-5-(2,3-Difluoro-6-Methoxybenzoyl)-2-Pyrimidinyl]-1-(Methylsulfonyl)-4-Piperidinamine Monomethanesulfonate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support your regulatory and development needs. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Single Unknown Impurity	≤0.5%
Total Impurities	≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.