Description

3',5'-Di-o-Acetyl-5-Fluoro-2'-o-Methyl-O4-(2,4,6-Trimethylphenyl)Uridine is a sophisticated, high-purity nucleoside derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block and key intermediate in the synthesis of modified oligonucleotides and nucleotide analogs. It is essential for researchers and manufacturers in the fields of antiviral drug development, oncology therapeutics, and probe synthesis for molecular biology. Our supply ensures consistent quality and reliable availability for global R&D and cGMP manufacturing processes.

Application

• Key Intermediate for Antiviral Prodrugs: A vital precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oligonucleotide Synthesis: Used in the solid-phase synthesis of modified RNA/DNA strands for therapeutic and diagnostic applications.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop novel nucleotide-based therapeutics.
• Biochemical Probe Development: Acts as a modified substrate for studying enzyme mechanisms, particularly polymerases and kinases.
• Pre-clinical & Clinical Trial Material: Supplied as a high-purity intermediate for the production of Active Pharmaceutical Ingredients (APIs) under development.
• Labeled Compound Synthesis: Serves as a starting point for introducing radioactive or stable isotopes for tracer studies.

Basic Information

Product Name	3',5'-Di-o-Acetyl-5-Fluoro-2'-o-Methyl-O4-(2,4,6-Trimethylphenyl)Uridine
CAS No.	869355-32-8
Molecular Formula	C23H25FN2O8
Molecular Weight	476.46 g/mol
Synonyms	5-Fluoro-2'-O-methyl-3',5'-di-O-acetyl-O4-(2,4,6-trimethylphenyl)uridine; 2'-O-Methyl-5-fluoro-3',5'-di-O-acetyl-O4-mesityluridine; 5-Fluoro-2'-O-methyl-3',5'-di-O-acetyl-O4-mesityluridine; Uridine, 3',5'-di-O-acetyl-5-fluoro-2'-O-methyl-O4-(2,4,6-trimethylphenyl)-; 869355-32-8; 5-Fluoro-2'-O-methyluridine 3',5'-diacetate O4-mesitylene derivative; Modified Uridine Intermediate
EINECS	Contact for details

Quality Control

Every batch of 3',5'-Di-o-Acetyl-5-Fluoro-2'-o-Methyl-O4-(2,4,6-Trimethylphenyl)Uridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and GMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.