Description

2'-Deoxy-5'-o-(Dimethoxytrityl)-5,6-Dihydrouridine is a sophisticated nucleoside derivative, specifically a protected form of 5,6-dihydrouridine, which is a modified nucleoside found in tRNA. This compound matters as a critical high-purity building block (phosphoramidite precursor) for oligonucleotide synthesis, enabling the study of RNA structure, function, and stability. It is essential for researchers and manufacturers in the fields of therapeutic oligonucleotide development, antisense technology, and molecular biology diagnostics who require reliable, high-quality synthetic intermediates.

Application

• Oligonucleotide Synthesis: Serves as a key protected monomer for the solid-phase synthesis of oligonucleotides containing modified bases.
• Antisense & siRNA Research: Used in the development of antisense oligonucleotides and small interfering RNAs (siRNAs) to study gene silencing and therapeutic applications.
• tRNA Mimic & Probe Development: Essential for creating probes and mimics that incorporate 5,6-dihydrouridine to study tRNA structure, function, and recognition.
• Pharmaceutical Intermediates: Acts as a crucial intermediate in the research and development stages of novel nucleoside-based pharmaceuticals.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor for nucleoside-metabolizing enzymes.
• Diagnostic Assay Development: Used in the design and production of specialized oligonucleotides for diagnostic kits and assays.

Basic Information

Product Name	2'-Deoxy-5'-o-(Dimethoxytrityl)-5,6-Dihydrouridine
CAS No.	869355-28-2
Molecular Formula	C31H32N2O7
Molecular Weight	544.60 g/mol
Synonyms	5,6-Dihydro-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine; 5,6-Dihydro-2'-deoxyuridine 5'-(4,4'-dimethoxytrityl) ether; DMT-dhU; 2'-Deoxy-5'-O-DMT-5,6-dihydrouridine; 5'-O-(4,4'-Dimethoxytrityl)-5,6-dihydro-2'-deoxyuridine; 5,6-Dihydro-2'-deoxy-5'-O-DMT-uridine; Protected 5,6-dihydro-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5'-o-(Dimethoxytrityl)-5,6-Dihydrouridine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) providing full specifications is supplied with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.