Description

S4-(2-Cyanoethyl)-4-Thiothymidine is a chemically modified nucleoside analog, a critical building block in advanced pharmaceutical and biochemical research. This compound matters for its role as a key intermediate in the synthesis of modified oligonucleotides and potential therapeutic agents, particularly in antiviral and anticancer drug discovery. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel nucleic acid-based therapies and diagnostic tools.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used in the solid-phase or solution-phase synthesis of modified DNA/RNA strands for research and therapeutic applications (e.g., antisense oligonucleotides, aptamers).
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related pathways.
• Probe Development: Utilized in creating labeled nucleotides for diagnostic assays and imaging techniques.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of nucleoside analogs.

Basic Information

Product Name	S4-(2-Cyanoethyl)-4-Thiothymidine
CAS No.	869355-26-0
Molecular Formula	C13H17N3O5S
Molecular Weight	327.36 g/mol
Synonyms	4-Thio-2'-deoxy-5-methyluridine 4-(2-cyanoethyl) disulfide; 4-S-(2-Cyanoethyl)-4-thiothymidine; 1-((2R,4S,5R)-4-((2-Cyanoethyl)thio)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-5-methyl-4-thiouridine S-(2-cyanoethyl) disulfide; 4-Thiothymidine S-2-cyanoethyl derivative
EINECS	Contact for details

Quality Control

Our S4-(2-Cyanoethyl)-4-Thiothymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.