Description

[E]-5-(2-Carbomethoxyvinyl)-5'-o-(Dimethoxytrityl)-2'-Deoxyuridine is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block for the controlled assembly of DNA sequences, enabling the production of primers, probes, and therapeutic oligonucleotides. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CROs engaged in antisense therapy, molecular diagnostics, and genetic research.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• Molecular Probe Fabrication: Enables the creation of labeled probes for diagnostic assays, PCR, and hybridization techniques.
• Academic & Industrial Research: A vital reagent for studying nucleic acid chemistry, structure, and function.
• Primer Design: Facilitates the synthesis of specialized primers with specific modifications for advanced sequencing and amplification protocols.

Basic Information

Product Name	[E]-5-(2-Carbomethoxyvinyl)-5'-o-(Dimethoxytrityl)-2'-Deoxyuridine
CAS No.	869355-22-6
Molecular Formula	C34H34N2O9
Molecular Weight	614.65 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-5-(2-methoxycarbonylvinyl)-2'-deoxyuridine; DMT-dU(CMV); 5-(2-Carbomethoxyvinyl)-2'-deoxyuridine 5'-O-(4,4'-dimethoxytrityl) ether; 5'-O-DMT-5-(2-carbomethoxyvinyl)-2'-deoxyuridine; Protected 5-Carbomethoxyvinyl-dU; Nucleoside Building Block 869355-22-6
EINECS	Contact for details

Quality Control

Our [E]-5-(2-Carbomethoxyvinyl)-5'-o-(Dimethoxytrityl)-2'-Deoxyuridine is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.