Description

Cytidine, n-Acetyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-o-Methyl-5-Methyl- is a sophisticated, protected nucleoside derivative designed for advanced oligonucleotide synthesis and pharmaceutical research. This high-purity intermediate is critical for the development of modified RNA and DNA sequences, enabling precise control over genetic material properties. It is primarily utilized by research institutions and pharmaceutical companies focused on antisense therapeutics, siRNA development, and other cutting-edge nucleic acid technologies.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a key phosphoramidite building block for the automated synthesis of modified RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of therapeutic oligonucleotides designed to target specific RNA sequences.
• Small Interfering RNA (siRNA) Manufacturing: A critical raw material for creating siRNA molecules with enhanced stability and specificity for gene silencing applications.
• Pharmaceutical Intermediate: Acts as a protected precursor in the multi-step synthesis of novel nucleoside-based antiviral or anticancer agents.
• Biochemical Research: Employed in academic and industrial labs to study RNA structure, function, and metabolism.
• Diagnostic Probe Development: Utilized in the creation of labeled nucleic acid probes for detection and diagnostic assays.

Basic Information

Product Name	Cytidine, n-Acetyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-o-Methyl-5-Methyl-
CAS No.	869355-20-4
Molecular Formula	C35H38N3O8
Molecular Weight	628.70 g/mol
Synonyms	5'-O-DMT-2'-O-Methyl-N4-acetyl-5-methylcytidine; 2'-O-Methyl-N4-acetyl-5-methylcytidine 5'-O-(4,4'-Dimethoxytrityl); N4-Acetyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-O-methyl-5-methylcytidine; 5-Methyl-2'-O-methyl-N4-acetylcytidine DMT ether; Protected 5-Methyl-2'-O-methylcytidine; DMT-2'-OMe-N4-Ac-5-Me-C; RNA Modification Intermediate; 5'-DMT-2'-O-Me-N4-Ac-5-Me-Cytidine
EINECS	Contact for details

Quality Control

Our production of this high-value nucleoside intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural integrity and purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.