Description

5'-O-(Dimethoxytrityl)-N2-Methyl-2'-Deoxyguanosine is a high-purity, chemically modified nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis. This compound is a critical building block in the production of antisense oligonucleotides and other therapeutic nucleic acids, where precise chemical modification is required to enhance stability, specificity, and pharmacokinetic properties. It is essential for research and development laboratories, as well as production facilities, in the pharmaceutical, biotechnology, and diagnostic sectors focused on next-generation genetic medicines.

Application

• Solid-Phase Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated synthesis of modified DNA strands.
• Antisense Oligonucleotide (ASO) Development: Used to incorporate N2-methylguanine modifications, which can improve target binding affinity and nuclease resistance.
• Therapeutic Aptamer Production: Enables the creation of chemically modified aptamers with enhanced biological activity and stability in vivo.
• siRNA and miRNA Research: Employed in the synthesis of guide strands for RNA interference applications where specific base modifications are needed.
• Diagnostic Probe Synthesis: Used to manufacture labeled or modified DNA probes for sensitive detection assays.
• Academic & Industrial R&D: Serves as a vital reagent for studying structure-activity relationships in nucleic acid chemistry.

Basic Information

Product Name	5'-O-(Dimethoxytrityl)-N2-Methyl-2'-Deoxyguanosine
CAS No.	869354-96-1
Molecular Formula	C31H33N5O6
Molecular Weight	571.63 g/mol
Synonyms	5'-O-DMT-N2-Methyl-2'-deoxyguanosine; N2-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine; DMT-dG(N2-Me) OH; 2'-Deoxy-N2-methyl-5'-O-(4,4'-dimethoxytrityl)guanosine; N2-Methyl-2'-deoxyguanosine, 5'-O-(4,4'-dimethoxytrityl) derivative; 5'-O-(Bis(4-methoxyphenyl)phenylmethoxy)-N2-methyl-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Every batch of 5'-O-(Dimethoxytrityl)-N2-Methyl-2'-Deoxyguanosine is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with high-purity standards suitable for pharmaceutical research and GMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive; it should be handled under anhydrous conditions and allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.