Description

5'-o-(Dimethoxytrityl)-N6-[((((3-Aminopropoxy(Ethoxy))-Ethoxy)Ethoxy)Ethoxy) Propyl]Adenosine is a sophisticated, high-purity nucleoside phosphoramidite derivative, engineered for precision in oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring reliable, high-yield coupling in the automated production of DNA and RNA sequences. It is an essential building block for the pharmaceutical, biotechnology, and diagnostic industries, particularly in the development of therapeutic oligonucleotides, primers, and probes.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): As a key phosphoramidite monomer for the automated synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense oligonucleotides (ASOs), siRNA, and aptamers for drug development.
• Diagnostic Probe Synthesis: Creation of labeled probes for PCR, qPCR, FISH, and microarray technologies.
• Research & Development: A vital reagent in academic and industrial labs for studying nucleic acid chemistry and function.
• Synthesis of Modified Nucleotides: Enables the incorporation of functionalized adenosine analogs with extended linker arms for conjugation.
• Bioconjugation: The extended aminopropoxy-ethoxy linker facilitates the attachment of fluorophores, quenchers, or other reporter molecules.

Basic Information

Product Name	5'-o-(Dimethoxytrityl)-N6-[((((3-Aminopropoxy(Ethoxy))-Ethoxy)Ethoxy)Ethoxy) Propyl]Adenosine
CAS No.	869354-92-7
Molecular Formula	C49H68N6O11
Molecular Weight	917.10 g/mol
Synonyms	5'-O-DMT-N6-(Amino-PEG4-propyl)-Adenosine; DMT-Amino-PEG4-Adenosine Phosphoramidite precursor; N6-(17-Amino-3,6,9,12,15-pentaoxaheptadec-1-yl)-5'-O-(4,4'-dimethoxytrityl)adenosine; Amino-PEG4-Adenosine DMT; 5'-O-(4,4'-Dimethoxytrityl)-N6-[3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propyl]adenosine
EINECS	Contact for details

Quality Control

Every batch of our nucleoside derivatives is produced and tested under strict quality management systems. We ensure compliance with the high-purity standards required for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity (HPLC), identity (NMR, MS), and moisture content. Our quality protocols are designed to meet the rigorous demands of GMP-grade manufacturing for therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DCM, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.