Description

8-Allyloxy-N2-Isobutyryl-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis and pharmaceutical research. This compound is a critical building block for the development of therapeutic nucleic acids, offering enhanced stability and targeted functionality. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other novel gene-targeting therapies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Therapy Development: Used in the research and production of antisense oligonucleotides designed to modulate gene expression.
• siRNA and miRNA Research: Serves as a modified base to enhance the nuclease resistance and pharmacokinetic properties of RNAi therapeutics.
• Pharmaceutical Intermediates: Acts as a high-value intermediate in the synthesis of novel nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• Bioconjugation and Probe Development: The allyloxy group provides a handle for further chemical modifications, useful in creating labeled probes for diagnostics.
• Academic and Industrial R&D: Employed in biochemical research to study nucleic acid structure, function, and protein interactions.

Basic Information

Product Name	8-Allyloxy-N2-Isobutyryl-2'-Deoxyguanosine
CAS No.	869354-75-6
Molecular Formula	C₁₇H₂₁N₅O₆
Molecular Weight	391.38 g/mol
Synonyms	8-Allyloxy-N2-isobutyryl-2'-deoxyguanosine; 2'-Deoxy-8-(allyloxy)-N2-(2-methylpropanoyl)guanosine; 2'-Deoxyguanosine, 8-(2-propen-1-yloxy)-N2-(2-methyl-1-oxopropyl)-; dG(ib,8al) Phosphoramidite precursor; Modified 2'-Deoxyguanosine derivative; N2-Isobutyryl-8-allyloxy-2'-deoxyguanosine; 8-Allyloxy-dG(Ibu)
EINECS	Contact for details

Quality Control

Our 8-Allyloxy-N2-Isobutyryl-2'-Deoxyguanosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality control protocols are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.