Description

8-Allyloxy-2'-Deoxyguanosine is a modified nucleoside analog, a key building block in oligonucleotide synthesis and medicinal chemistry research. This compound matters for its role in introducing specific functional groups into nucleic acid structures, enabling advanced studies in drug discovery, antisense technology, and molecular biology. Researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors need this high-purity intermediate to develop novel therapeutic agents and sophisticated molecular probes.

Application

• Oligonucleotide Synthesis: Serves as a crucial phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate functionalized nucleosides into oligonucleotides designed for gene silencing and targeted therapeutic applications.
• Medicinal Chemistry & Drug Discovery: Acts as a versatile intermediate for the development of nucleoside-based prodrugs and antiviral/anticancer agents.
• Bioconjugation & Labeling: The allyloxy group provides a handle for further chemical modification, enabling site-specific conjugation with fluorophores, affinity tags, or other molecules.
• Structural Biology Studies: Employed to create modified nucleic acids for investigating enzyme mechanisms, such as those of polymerases and nucleases.
• Diagnostic Probe Development: Utilized in the manufacture of high-specificity probes for PCR, sequencing, and microarray technologies.

Basic Information

Item	Detail
Product Name	8-Allyloxy-2'-Deoxyguanosine
CAS No.	869354-71-2
Molecular Formula	C13H17N5O5
Molecular Weight	323.31 g/mol
Synonyms	8-Allyloxy-deoxyguanosine; 2'-Deoxy-8-(allyloxy)guanosine; 8-O-Allyl-2'-deoxyguanosine; dG(8-O-allyl); 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-(prop-2-enoxy)-3H-purin-6-one; 8-AllyloxydG; Modified Deoxyguanosine Nucleoside
EINECS	Contact for details

Quality Control

Our 8-Allyloxy-2'-Deoxyguanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.