Description

(E)-5-[3-(Trifluoroacetamido)-1-Propenyl]Uridine is a specialized nucleoside analog derivative, a key intermediate in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of modified oligonucleotides and nucleotide-based therapeutics, enabling targeted drug discovery. It is primarily required by research institutions and pharmaceutical companies engaged in developing antiviral agents, anticancer drugs, and novel molecular probes. Our supply ensures high-purity material critical for reliable and reproducible experimental outcomes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for antisense therapy, siRNA, and aptamer development.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and related pathways.
• Proteomics & Molecular Biology: Employed in the development of cross-linking agents or labeled probes for studying nucleic acid-protein interactions.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Diagnostic Reagent Development: Potential use in creating components for diagnostic assays targeting specific genetic markers.

Basic Information

Product Name	(E)-5-[3-(Trifluoroacetamido)-1-Propenyl]Uridine
CAS No.	869222-68-4
Molecular Formula	C14H16F3N3O7
Molecular Weight	395.29 g/mol
Synonyms	5-[(1E)-3-[(2,2,2-Trifluoroacetyl)amino]-1-propen-1-yl]uridine; 5-[3-(Trifluoroacetamido)-1-propenyl]uridine; Uridine, 5-[3-[(trifluoroacetyl)amino]-1-propenyl]-, (E)-; 5-(3-Trifluoroacetamidoprop-1-en-1-yl)uridine; N-Trifluoroacetyl-5-(1-propenyl)uridine derivative; 869222-68-4; (E)-5-(3-Trifluoroacetamidoprop-1-enyl)uridine
EINECS	Contact for details

Quality Control

Our (E)-5-[3-(Trifluoroacetamido)-1-Propenyl]Uridine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements. We support custom synthesis to meet specific purity or packaging needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.