Description

Benzyl-Peg8-Azide is a heterobifunctional polyethylene glycol (PEG) linker featuring a benzyl-protected hydroxyl group and a terminal azide functionality. This compound is a critical reagent in bioconjugation and click chemistry, enabling the precise, high-yield coupling of biomolecules and polymers under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, high-purity linkers for creating stable, functionalized conjugates.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a hydrophilic spacer to link cytotoxic drugs to monoclonal antibodies, improving solubility and pharmacokinetics.
• PEGylation of Peptides and Proteins: Serves as a functionalized PEG derivative for modifying therapeutic biomolecules to enhance stability and reduce immunogenicity.
• Click Chemistry Synthesis: The terminal azide group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) for highly specific ligation with alkyne-modified molecules.
• Polymer and Hydrogel Functionalization: A key building block for introducing reactive sites into polymer backbones or cross-linked networks for biomedical applications.
• Surface Modification and Immobilization: Used to create azide-functionalized surfaces for the subsequent attachment of biomolecules via click chemistry.
• Diagnostic Reagent and Probe Synthesis: Facilitates the creation of labeled probes for imaging, biosensing, and diagnostic assays.
• Nanoparticle and Liposome Functionalization: Enables the targeted functionalization of drug delivery carriers for enhanced therapeutic efficacy.
• Cross-linking Agent for Biomaterials: Used in the development of novel biomaterials with tailored mechanical and biological properties.

Basic Information

Product Name	Benzyl-Peg8-Azide
CAS No.	868594-42-7
Molecular Formula	C30H53N3O11
Molecular Weight	631.76 g/mol
Synonyms	1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl Benzoate; Benzyl-PEG8-N3; Benzyl-PEG8-Azide; Benzyl-PEG8-N3; Benzyl-PEG8-Azide; 2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl Benzoate; Azido-PEG8-Benzyl Ester; Benzyl Ester-PEG8-Azide
EINECS	Contact for details

Quality Control

Our Benzyl-Peg8-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and FTIR for functional group verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is strictly light-sensitive and should be protected from all light exposure during handling and storage. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (NMR)	Conforms to structure
Identification (IR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.