Description

Imetelstat is a potent and specific telomerase inhibitor, representing a significant advancement in targeted therapeutic research. This compound is of critical importance for its role in investigating cellular senescence and proliferation pathways in oncology and age-related diseases. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel cancer treatments and anti-aging therapies.

Application

• Oncology Research: Key investigational agent for targeting telomerase activity in various cancer cell lines and preclinical models, including myelofibrosis and myelodysplastic syndromes.
• Drug Discovery & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the development of novel telomerase-inhibiting therapeutics.
• Biochemical & Pharmacological Studies: Used to study the mechanisms of telomere maintenance, cellular immortality, and apoptosis in experimental settings.
• Academic Research: Essential tool for universities and research institutes exploring the fundamental biology of aging, cancer, and stem cell regulation.
• Biomarker & Diagnostic Development: Employed in assays to understand telomerase expression and activity as a potential diagnostic or prognostic marker.
• Formulation Development: Used in stability studies and the development of parenteral or other dosage forms for clinical trial materials.

Basic Information

Product Name	Imetelstat
CAS No.	868169-64-6
Molecular Formula	C78H111N23O26
Molecular Weight	1690.85 g/mol
Synonyms	GRN163L; Imetelstat sodium; Telomerase Inhibitor GRN163L; 13-mer Thio-phosphoramidate Oligonucleotide (NPS'0006); 5'-TAGGGTTAGACAA-NH2-3' (Thio-phosphoramidate); GRN-163L; Telomerase antagonist GRN163L
EINECS	Contact for details

Quality Control

Our Imetelstat is manufactured under strict quality management systems to ensure the highest standards for research and development use. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and strength. We adhere to relevant guidelines for advanced pharmaceutical intermediates and reference standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage, consider desiccation or under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Endotoxin (LAL)	< 10 EU/mg
Sterility (for applicable grades)	Sterile or Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.