Description

Linsitinib CAS NO 867160-71-2 is a potent and selective small-molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase. This compound is a critical research tool for investigating the IGF-1R signaling pathway, which plays a significant role in cell growth, proliferation, and survival. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology research and drug discovery programs.

Application

• Oncology Research: Used as a reference standard and pharmacological tool to study the role of IGF-1R in various cancer models, including breast, lung, and colorectal cancers.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of targeted cancer therapies.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro kinase assays to evaluate the potency and selectivity of novel IGF-1R inhibitors.
• Mechanistic Studies: Facilitates research into cell proliferation, apoptosis, and signal transduction pathways mediated by IGF-1R and related receptors.
• Reference Standard: Provides a certified standard for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	Linsitinib
CAS No.	867160-71-2
Molecular Formula	C₂₆H₂₃N₅O₃
Molecular Weight	453.49 g/mol
Synonyms	OSI-906; IGF-1R Inhibitor OSI-906; (3E)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
EINECS	Contact for details

Quality Control

Our Linsitinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing full specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.