Description

Uridine, 2'-Deoxy-5-[(1E)-1,2-Dibromoethenyl]- (9Ci) CAS NO 866836-88-6 is a specialized, halogenated nucleoside derivative of significant interest in advanced organic synthesis and medicinal chemistry research. This compound serves as a crucial synthetic intermediate for the development of novel antiviral and anticancer agents, where its unique dibromoethenyl moiety enables targeted molecular modifications. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in nucleoside chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analog prodrugs with potential antiviral or anticancer activity.
• Medicinal Chemistry Research: Used as a precursor for structure-activity relationship (SAR) studies to optimize the biological activity and pharmacokinetic properties of therapeutic candidates.
• Biochemical Probe Development: Serves as a modified nucleoside substrate for studying enzyme mechanisms, particularly those involving DNA/RNA polymerases and repair enzymes.
• Organic Synthesis: Valuable intermediate in complex multi-step syntheses, leveraging the reactivity of the dibromoethenyl group for further functionalization via cross-coupling or substitution reactions.
• Antiviral Agent Research: Investigated for the development of compounds targeting viral polymerases, given its structural similarity to natural nucleosides.

Basic Information

Product Name	Uridine, 2'-Deoxy-5-[(1E)-1,2-Dibromoethenyl]- (9Ci)
CAS No.	866836-88-6
Molecular Formula	C11H12Br2N2O5
Molecular Weight	412.04 g/mol
Synonyms	2'-Deoxy-5-[(1E)-1,2-dibromoethenyl]uridine; 5-[(1E)-1,2-Dibromoethenyl]-2'-deoxyuridine; (E)-5-(1,2-Dibromovinyl)-2'-deoxyuridine; DBVDU; 5-(1,2-Dibromovinyl)-2'-deoxyuridine; 2'-Deoxy-5-(1,2-dibromovinyl)uridine; 866836-88-6; (E)-5-(1,2-Dibromoethenyl)-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our Uridine, 2'-Deoxy-5-[(1E)-1,2-Dibromoethenyl]- (9Ci) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and biotechnology partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.