Description

4,5-Dimethoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is a high-value organosilicon building block and triflate ester reagent. This compound is critical for facilitating challenging cross-coupling reactions and serving as a protected intermediate in complex organic synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for complex molecules requiring silicon-directed ortho-lithiation or palladium-catalyzed coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that incorporate silicon and aryl ether motifs.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Acts as an excellent electrophile in Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions due to the superior leaving group ability of the triflate moiety.
• Directed Ortho-Metalation (DoM) Synthon: The trimethylsilyl group acts as a powerful directing group for regioselective lithiation, enabling precise functionalization of the arene ring.
• Laboratory Research & Development: Essential reagent for methodological studies and constructing complex, polyfunctional aromatic compounds in academic and industrial research settings.

Basic Information

Product Name	4,5-Dimethoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	866252-52-0
Molecular Formula	C₁₂H₁₇F₃O₅SSi
Molecular Weight	358.41 g/mol
Synonyms	2-(Trimethylsilyl)-4,5-dimethoxyphenyl triflate; 4,5-Dimethoxy-2-(trimethylsilyl)phenyl triflate; 1-(Trimethylsilyl)-2,3-dimethoxy-6-(trifluoromethanesulfonyloxy)benzene; TMS-Dimethoxyphenyl Triflate; Trifluoromethanesulfonic Acid 4,5-Dimethoxy-2-(Trimethylsilyl)Phenyl Ester
EINECS	Contact for details

Quality Control

Our production of 4,5-Dimethoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized by NMR (¹H, ¹³C), HPLC, and GC analysis to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.