Description

5-(4-Isopropyl-Phenyl)-7-Trifluoromethyl-Pyrazolo-[1,5-A]Pyrimidine-2-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its pyrazolopyrimidine core and acid chloride functional group. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, enabling the introduction of a key pharmacophore. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic structure.
• Chemical Research & Development: Serves as a versatile building block for constructing complex heterocyclic compounds in medicinal and synthetic chemistry.
• Material Science Precursor: Potential use in the development of advanced organic materials and functional dyes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for studying novel organic reactions and biological activity.

Basic Information

Product Name	5-(4-Isopropyl-Phenyl)-7-Trifluoromethyl-Pyrazolo-[1,5-A]Pyrimidine-2-Carbonyl Chloride
CAS No.	865412-32-4
Molecular Formula	C₁₇H₁₃ClF₃N₃O
Molecular Weight	367.75 g/mol
Synonyms	5-(4-Isopropylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride; 7-Trifluoromethyl-5-(p-isopropylphenyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride; Pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride, 5-[4-(1-methylethyl)phenyl]-7-(trifluoromethyl)-; 865412-32-4; 5-(4-Isopropyl-Phenyl)-7-Trifluoromethyl-Pyrazolo[1,5-A]Pyrimidine-2-Carbonyl Chloride
EINECS	Contact for details

Quality Control

Our 5-(4-Isopropyl-Phenyl)-7-Trifluoromethyl-Pyrazolo-[1,5-A]Pyrimidine-2-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for pharmaceutical development, and we can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.