Description

2'-Deoxy-5'-o-Dmt-N2-Isopropylguanosine is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound matters as a critical building block for the solid-phase assembly of DNA and RNA sequences, enabling precise genetic research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories engaged in antisense therapy, diagnostic probe development, and synthetic biology.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for automated solid-phase synthesis of DNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• PCR Probe & Primer Manufacturing: Essential for creating high-specificity probes and primers used in diagnostic assays and genetic testing.
• Synthetic Biology: Serves as a foundational component for constructing artificial genes and genetic circuits.
• Research Reagent: Employed in academic and industrial research for studying nucleic acid structure, function, and interactions.
• Next-Generation Sequencing (NGS): Used in the development of specialized nucleotides for advanced sequencing platforms.

Basic Information

Product Name	2'-Deoxy-5'-o-Dmt-N2-Isopropylguanosine
CAS No.	863910-15-0
Molecular Formula	C33H41N5O7
Molecular Weight	619.71 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N2-isopropyl-2'-deoxyguanosine; N2-Isopropyl-5'-O-DMT-2'-deoxyguanosine; DMT-dG(iPr) Phosphoramidite precursor; N2-iPr-dG(DMT); 2'-Deoxy-N2-isopropylguanosine 5'-O-DMT ether; Protected Isopropyl-dG; Guanosine, 2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N2-(1-methylethyl)-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5'-o-Dmt-N2-Isopropylguanosine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) with full traceability are provided to support your GMP or research documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccant in a sealed secondary container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.