Description

2'-Deoxy-2'-Fluoro-2'-C-Methyluridine is a high-purity fluorinated nucleoside analog, a critical building block in advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of novel antiviral and anticancer therapeutics, particularly in the development of modified RNA and nucleotide prodrugs. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality raw materials for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of antiviral drugs, including potential treatments for Hepatitis C Virus (HCV) and other RNA viruses.
• Anticancer Drug Development: Serves as a building block for nucleoside analogs designed to inhibit cancer cell proliferation.
• ProTide Technology: Used in the development of phosphoramidate prodrugs (ProTides) to enhance cellular delivery and therapeutic efficacy of nucleotide analogs.
• Biochemical Research: Employed in studies of RNA metabolism, enzyme inhibition, and the mechanism of action of antiviral agents.
• Process Chemistry & Scale-Up: Sourced by fine chemical manufacturers for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	2'-Deoxy-2'-Fluoro-2'-C-Methyluridine
CAS No.	863329-66-2
Molecular Formula	C10H13FN2O5
Molecular Weight	260.22 g/mol
Synonyms	2'-Deoxy-2'-fluoro-2'-C-methyluridine; 2'-Fluoro-2'-C-methyluridine; 2'-F-2'-C-Me-Uridine; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-Fluoro-2'-methyluridine; PSI-6130 intermediate; RO2433
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro-2'-C-Methyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters are provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.