Description

Sti-571 Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) with the CAS registry number 862366-25-4. This compound is critical for research and development in targeted cancer therapies, particularly as a precursor in the synthesis of kinase inhibitors. It is essential for pharmaceutical manufacturers, biotechnology research laboratories, and academic institutions focused on oncology and signal transduction pathway studies.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of targeted tyrosine kinase inhibitor APIs.
• Oncology Research: Utilized in preclinical and clinical research for studying chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST).
• Biochemical Assay Development: Serves as a reference standard and active component in cell-based and enzymatic assays for drug discovery.
• Academic & Institutional Research: Used in universities and research institutes for investigating Bcr-Abl and c-Kit signaling pathways.
• GMP Manufacturing: Sourced by contract development and manufacturing organizations (CDMOs) for the production of finished dosage forms under Good Manufacturing Practices.
• Reference Standard: Qualified for use as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Sti-571 Hydrochloride
CAS No.	862366-25-4
Molecular Formula	C₂₉H₃₂ClN₇O • HCl
Molecular Weight	589.96 g/mol
Synonyms	Imatinib Hydrochloride; STI571 Hydrochloride; Gleevec Hydrochloride; Glivec Hydrochloride; CGP 57148B; 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Monohydrochloride; Imatinib Monohydrochloride
EINECS	Contact for details

Quality Control

Our Sti-571 Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for advanced pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material that meets in-house specifications aligned with pharmacopeial standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.