Description

3-Bromo-Pyrazolo[1,5-A]Pyrimidine-2-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its bromo-substituted fused heterocyclic structure and an acid chloride functional group. This compound matters for its critical role as a versatile building block in modern organic synthesis, enabling the efficient construction of complex molecular architectures. It is primarily needed by pharmaceutical and agrochemical R&D departments for the development of novel active ingredients, particularly in medicinal chemistry for creating targeted small-molecule libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as ligands for catalysts or components for organic electronics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical reactions involving halogenated heterocycles.

Basic Information

Product Name	3-Bromo-Pyrazolo[1,5-A]Pyrimidine-2-Carbonyl Chloride
CAS No.	861224-59-1
Molecular Formula	C7H3BrClN3O
Molecular Weight	260.47 g/mol
Synonyms	3-Bromopyrazolo[1,5-a]pyrimidine-2-carbonyl chloride; 2-Pyrazolo[1,5-a]pyrimidinecarbonyl chloride, 3-bromo-; 3-Bromo-2-pyrazolo[1,5-a]pyrimidinecarbonyl chloride; 3-Bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid chloride; 861224-59-1; 3-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-Pyrazolo[1,5-A]Pyrimidine-2-Carbonyl Chloride is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and specifications can be aligned with client-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.