Description

n-(9-((3S,4R,5S)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-3-Yl)-6-Oxo-6,9-Dihydro-1H-Purin-2-Yl)Propionamide is a high-purity, nucleoside-derived building block of significant importance in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of modified oligonucleotides and nucleotide analogs, enabling the development of targeted therapeutics. It is essential for researchers and manufacturers in the fields of antisense technology, siRNA development, and diagnostic probe synthesis who require reliable, high-quality chemical intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleotide-based active pharmaceutical ingredients (APIs).
• Antisense Oligonucleotide (ASO) Synthesis: Used in the solid-phase or solution-phase synthesis of antisense drugs targeting specific mRNA sequences.
• siRNA and miRNA Precursor: Critical for constructing chemically modified small interfering RNA (siRNA) and microRNA (miRNA) molecules to enhance stability and efficacy.
• Diagnostic Probe Development: Employed in creating labeled nucleotide probes for genetic testing, fluorescence in situ hybridization (FISH), and other molecular diagnostics.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs focused on nucleoside analogs.
• Bioconjugation: The propionamide moiety can be utilized for further functionalization and conjugation to delivery vehicles or other biomolecules.

Basic Information

Product Name	n-(9-((3S,4R,5S)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-3-Yl)-6-Oxo-6,9-Dihydro-1H-Purin-2-Yl)Propionamide
CAS No.	861151-92-0
Molecular Formula	C40H39N5O7
Molecular Weight	701.77 g/mol
Synonyms	2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-propionyl-2-aminoadenosine; DMT-rA(Pr)-CE Phosphoramidite precursor; N6-Propionyl-2'-deoxy-5'-O-DMT-adenosine; 2-Amino-N6-propionyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine; 2'-Deoxy-N6-propionyl-5'-O-DMT-2-aminoadenosine; Protected 2-Aminoadenosine Derivative; DMT-dA(Pr) Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is thoroughly characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.