Description

Bafetinib is a potent and selective small-molecule inhibitor of the Bcr-Abl and Lyn tyrosine kinases. This compound matters as a key research tool and pharmaceutical intermediate in the development of targeted cancer therapies, particularly for chronic myeloid leukemia (CML). It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology and kinase signaling pathways.

Application

• Pharmaceutical Research & Development: As a critical intermediate or reference standard in the synthesis and development of novel tyrosine kinase inhibitors for cancer treatment.
• Oncology Studies: Used in biochemical and cellular assays to study Bcr-Abl and Lyn kinase inhibition, apoptosis, and cell proliferation mechanisms.
• Preclinical Research: Employed in in vitro and in vivo models to evaluate the efficacy and pharmacokinetics of targeted leukemia therapies.
• Chemical Biology: A valuable tool compound for probing kinase-dependent signaling networks and validating new drug targets.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical manufacturing.

Basic Information

Product Name	Bafetinib
CAS No.	859212-16-1
Molecular Formula	C30H31N7O3
Molecular Weight	537.61 g/mol
Synonyms	INNO-406; NS-187; 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide; (E)-N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
EINECS	Contact for details

Quality Control

Our Bafetinib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.