Description

[4-Nitro-2-(Trifluoromethyl)Phenyl]Methanol, also known as 2-(Hydroxymethyl)-5-Nitrobenzotrifluoride, is a high-value aromatic building block characterized by its nitro and trifluoromethyl substituents. This compound is critical for synthesizing advanced molecules where electronic and steric properties must be precisely tuned. It is primarily sought after by research chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the nitro and trifluoromethyl groups.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in catalysis and as a building block for functional materials.
• Organic Electronic Materials: Employed in the synthesis of specialty monomers and polymers for optoelectronic applications due to its electron-withdrawing substituents.
• Dye and Pigment Intermediate: Acts as a starting material for the synthesis of complex, high-performance colorants.
• Custom Synthesis and Contract Research: A valuable reagent for custom synthesis houses and R&D laboratories conducting proprietary chemical research.

Basic Information

Product Name	[4-Nitro-2-(Trifluoromethyl)Phenyl]Methanol / 2-(Hydroxymethyl)-5-Nitrobenzotrifluoride
CAS No.	859027-06-8
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	(4-Nitro-2-(trifluoromethyl)phenyl)methanol; 2-(Hydroxymethyl)-α,α,α-trifluoro-5-nitrotoluene; 5-Nitro-2-(trifluoromethyl)benzyl alcohol; α,α,α-Trifluoro-5-nitro-o-tolylcarbinol; 2-(Trifluoromethyl)-4-nitrobenzyl alcohol; 4-Nitro-α,α,α-trifluoro-o-tolylmethanol; 859027-06-8
EINECS	Contact for details

Quality Control

Our production of [4-Nitro-2-(Trifluoromethyl)Phenyl]Methanol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.