Description

N3-Peg8-Tos CAS NO 857892-34-3 is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide (N3) group and a tosylate (Tos) leaving group, separated by an eight-unit PEG spacer. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific coupling of biomolecules, polymers, and nanoparticles under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, materials science, and diagnostic assay production who require reliable, high-purity linkers for constructing advanced therapeutic and diagnostic platforms.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: The azide group enables copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-modified drugs or probes, while the tosylate can be displaced by nucleophiles (e.g., thiols, amines) on proteins or antibodies.
• PEGylation of Therapeutics: Used to introduce PEG chains onto drug molecules or peptides via the reactive tosylate end, improving pharmacokinetic properties such as solubility, stability, and circulation half-life.
• Polymer and Hydrogel Synthesis: Serves as a versatile crosslinker or functionalization agent in creating smart materials, where the azide allows for subsequent "click" functionalization with various complementary groups.
• Surface Functionalization and Nanomaterial Modification: Facilitates the attachment of functional ligands, dyes, or biomolecules to nanoparticles, quantum dots, or biosensor surfaces for targeted delivery and imaging.
• Diagnostic Reagent and Probe Construction: Enables the assembly of complex detection probes by linking recognition elements (e.g., antibodies, oligonucleotides) to signal-generating molecules (e.g., fluorophores, enzymes).
• Chemical Biology and Proteomics Research: A key tool for labeling, pull-down assays, and studying biomolecular interactions in living systems through bioorthogonal chemistry.

Basic Information

Product Name	N3-Peg8-Tos CAS NO 857892-34-3
CAS No.	857892-34-3
Molecular Formula	C31H55N3O12S
Molecular Weight	669.85 g/mol
Synonyms	Azido-PEG8-tosylate; 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-yl 4-methylbenzenesulfonate, 24-azido; 24-Azido-3,6,9,12,15,18,21-heptaoxatetracosan-1-yl 4-methylbenzenesulfonate; N3-PEG8-OTs; Azido-PEG8-OTs; 1-Azido-3,6,9,12,15,18,21-heptaoxatricosan-23-yl 4-methylbenzenesulfonate; PEG8 azide tosylate; Heterobifunctional PEG linker N3-PEG8-OTs
EINECS	Contact for details

Quality Control

Our N3-Peg8-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize degradation due to moisture sensitivity and to maintain long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.