Description

Amg-706 is a high-purity small molecule compound with the CAS registry number 857876-30-3, widely recognized for its role as a potent and selective multi-targeted receptor tyrosine kinase inhibitor. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in oncology and angiogenesis-related therapeutic discovery.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-cancer therapies.
• Biochemical Assays: Used as a potent inhibitor in kinase profiling and cellular signaling pathway studies to understand tumor growth and metastasis.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and safety profiles of targeted cancer treatments.
• Academic Research: A valuable tool for investigating angiogenesis and the role of specific tyrosine kinases in various disease pathologies.
• Drug Discovery Screening: Used in high-throughput screening (HTS) libraries to identify and validate new drug candidates targeting similar pathways.

Basic Information

Product Name	Amg-706
CAS No.	857876-30-3
Molecular Formula	C₂₂H₁₈FN₃O₃
Molecular Weight	391.40 g/mol
Synonyms	Motesanib; Motesanib diphosphate; AMG-706; N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide; Motesanib (AMG 706); AMG706; UNII-8P8Q6LUE8H
EINECS	Contact for details

Quality Control

Our Amg-706 is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.