Description

2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-4-Carbonyl Chloride is a high-value organic intermediate characterized by its reactive carbonyl chloride group and trifluoromethylphenyl-thiazole core structure. This compound is critical for the synthesis of complex molecules where the introduction of a thiazole moiety and a fluorine-containing aromatic group is required. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands or monomers in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Employed in the creation of fluorescent tags or affinity probes for studying biological processes, leveraging the unique electronic properties of the thiazole ring.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-4-Carbonyl Chloride
CAS No.	857284-28-7
Molecular Formula	C11H5ClF3NOS
Molecular Weight	291.67 g/mol
Synonyms	4-(Trifluoromethyl)phenyl-thiazole-4-carbonyl chloride; 2-[4-(Trifluoromethyl)phenyl]-4-thiazolecarbonyl chloride; 1,3-Thiazole-4-carbonyl chloride, 2-[4-(trifluoromethyl)phenyl]-; 4-Carbonyl chloride-2-(4-trifluoromethylphenyl)thiazole; 2-(4-Trifluoromethylphenyl)thiazole-4-carbonyl chloride; 857284-28-7; α-(4-Trifluoromethylphenyl)-4-thiazolecarbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-4-Carbonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its nature as an acid chloride, it is moisture-sensitive and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and reactivity. Recommended storage temperature: 2-8°C for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.