Description

2,4-Diphenyl-1,3-thiazole-5-carbonyl chloride is a high-purity, reactive acid chloride derivative of a substituted thiazole heterocycle. This compound serves as a critical pharmaceutical intermediate and organic synthesis building block, enabling the efficient introduction of the 2,4-diphenylthiazole moiety into more complex molecular architectures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry research targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, or insecticides that incorporate the thiazole scaffold.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized ligands used in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, or fluorescent dyes due to the conjugated nature of the diphenylthiazole system.
• Peptide Mimetics and Bioconjugation: The reactive acyl chloride group allows for coupling with amines, facilitating the creation of amide bonds in complex organic molecules or bioconjugates.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring this specific molecular handle.

Basic Information

Product Name	2,4-Diphenyl-1,3-thiazole-5-carbonyl chloride
CAS No.	857284-13-0
Molecular Formula	C16H10ClNOS
Molecular Weight	299.77 g/mol
Synonyms	5-Carbonylchloride-2,4-diphenylthiazole; 2,4-Diphenylthiazole-5-carbonyl chloride; 2,4-Diphenyl-1,3-thiazole-5-carboxylic acid chloride; 5-Chlorocarbonyl-2,4-diphenylthiazole; 2,4-Diphenylthiazole-5-carboxylic chloride; (2,4-Diphenyl-1,3-thiazol-5-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2,4-Diphenyl-1,3-thiazole-5-carbonyl chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to current Good Manufacturing Practices (cGMP) where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring it meets the stringent requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.