Description

(3R,5S)-5-((S)-8-Fluoro-4-Isopropyl-2-(n-Methylmethyl Sulfonamido)-5,6-Dihydrobenzo[H]Quinazolin-6-Yl)-3,5- Dihydroxypentanoate Calcium(Ii) is a high-purity, complex synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is critical for its role in the synthesis of novel, targeted therapeutic agents, particularly in oncology and metabolic disease research. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of sophisticated active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of investigational new drugs, particularly those targeting specific enzyme pathways.
• Oncology Research: Used in the development of novel kinase inhibitors and other targeted cancer therapies due to its quinazoline-derived core structure.
• Metabolic Disorder Research: Serves as a precursor in the synthesis of compounds being studied for metabolic syndrome, diabetes, and related conditions.
• Process Chemistry Development: Employed by process chemists to optimize scalable and cost-effective synthetic routes for complex molecules.
• Reference Standard: Utilized as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Academic & Institutional Research: Supports chemical biology and medicinal chemistry programs in universities and research institutes exploring new chemical entities.

Basic Information

Product Name	(3R,5S)-5-((S)-8-Fluoro-4-Isopropyl-2-(n-Methylmethyl Sulfonamido)-5,6-Dihydrobenzo[H]Quinazolin-6-Yl)-3,5- Dihydroxypentanoate Calcium(Ii)
CAS No.	854898-50-3
Molecular Formula	C28H35CaF N3O7S
Molecular Weight	624.74 g/mol
Synonyms	Calcium (3R,5S)-5-((S)-8-fluoro-4-isopropyl-2-(N-methylsulfamoyl)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate; 854898-50-3; Calcium salt of (3R,5S)-Rosuvastatin intermediate; Dihydrobenzo[h]quinazoline calcium salt; Fluorinated quinazoline calcium complex; N-Methyl-N-(methylsulfonyl)quinazoline calcium derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent GMP (Good Manufacturing Practice) guidelines where applicable, ensuring traceability and consistency across all batches. Every lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.