Description

(3R,5S)-5-((R)-8-Fluoro-4-Isopropyl-2-(n-Methylmethylsulfonamido)-5,6-Hydrobenzo[H]Quinazolin-6-Yl)-3,5-Dihydroxypentanoate Calcium(Ii) is a high-purity, complex synthetic intermediate of significant importance in modern pharmaceutical research and development. This compound is valued for its specific stereochemistry and functional groups, which make it a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers focused on producing novel therapeutics, particularly in oncology and other specialized disease areas.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly in oncology research.
• Process Chemistry Development: Used for route scouting, optimization, and scale-up studies for new chemical entities (NCEs).
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in API manufacturing.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of novel pharmacophores in drug discovery programs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for advanced studies in synthetic organic chemistry and pharmacology.

Basic Information

Product Name	(3R,5S)-5-((R)-8-Fluoro-4-Isopropyl-2-(n-Methylmethylsulfonamido)-5,6-Hydrobenzo[H]Quinazolin-6-Yl)-3,5-Dihydroxypentanoate Calcium(Ii)
CAS No.	854898-48-9
Molecular Formula	C28H34CaFN3O7S
Molecular Weight	615.73 g/mol
Synonyms	Calcium (3R,5S)-5-((R)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate; 854898-48-9; (3R,5S)-Rosuvastatin Calcium Intermediate; Rosuvastatin Calcium Related Compound; Benzo[h]quinazoline calcium salt; Fluorinated quinazoline calcium complex; Calcium pentanoate derivative; Advanced statin intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support development under cGMP guidelines for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.